Without giving it too much thought, I'd say Knights of Cydonia, by Muse. A massive track, ever tried bombing down the motorway with that on full blast?
That Top 10 someone posted a couple of pages back is disgusting.
Also, I agree with top_spin that the Kings of Leon's newer stuff is far too revered when it's actually their weakest work. Their earlier stuff was so much more creative and their frantic energy on Aha Shake Heartbreak was a joy. Tracks like Arizona are awesome, but their latest album, while still decent, is a total sellout.